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Luo YJ，Wang YY，Pang YZ，Shen GA，Guo BL. Research progress of UbiA membrane-bound aromatic prenyltransferases in plants[J]. Plant Science Journal，2023，41（2）：256−268. DOI: 10.11913/PSJ.2095-0837.22147
Citation: Luo YJ，Wang YY，Pang YZ，Shen GA，Guo BL. Research progress of UbiA membrane-bound aromatic prenyltransferases in plants[J]. Plant Science Journal，2023，41（2）：256−268. DOI: 10.11913/PSJ.2095-0837.22147
shu

Research progress of UbiA membrane-bound aromatic prenyltransferases in plants

  • 1.

    Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicines, Ministry of Education, Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100193, China

  • 2.

    Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing 100193, China

Funds: This work was supported by a grant from the CAMS Innovation Fund for Medical Sciences (2021-I2M-1-031).
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  • Received Date: September 14, 2022
  • Revised Date: November 02, 2022
  • Available Online: May 05, 2023
    Graphical Abstract
    • Abstract

  • UbiA membrane-bound aromatic prenyltransferases (UbiA PTs) catalyze the transfer of prenyl moieties to aromatic acceptor molecules to form C-C or C-O bonds, and participate in the biosynthesis of important plant chemicals, including ubiquinone, plastoquinone, chlorophyll, and tocopherol. A variety of aromatic secondary metabolites with prenyl groups in plants are also products of this class of enzyme. The introduction of prenyl groups increases the structural diversity and biological activity of natural products. In this paper, we introduce the basic types of UbiA families in plants, summarize the substrate selectivity and catalytic characteristics of 57 UbiA PTs related to biosynthesis of secondary metabolites (flavonoids, coumarins, stilbenes), and discuss their phylogenetic relationship with primary metabolism-related PTs. We also discuss the exploration strategies of prenyltransferase genes and the application prospects of targeted synthesis of active prenylated compounds by microbial metabolic engineering.

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