Abstract: Brown planthopper (Nilaparvata lugens (Stål),BPH) and whitebacked planthopper (Sogatella furcifera Horvath,WBPH) are the phloem-sucking herbivores of rice.We employed cDNA-amplified fragment length polymorphism (cDNA-AFLP) technique to characterize the mole-(cular) responses of wild rice Oryza officinalis Wall ex Watt to BPH and WBPH feeding.After investigating about 7% of the insects-responsive transcriptome,we isolated 258 differential transcript-derived fragments (TDFs) and sequenced 112,of which 44 presented similarities to known or putative functional proteins.Among these 44 TDFs,35 TDFs were altered by WBPH-feeding while 24 were by BPH-feeding.There were more down-regulated TDFs than the up-regulated ones found after fed by BPH and WBPH.Only 2 TDFs were co-induced but 12 were co-suppressed by two planthoppers feeding.The results revealed that O.officinalis responded differentially to these two phloem herbivores.