Abstract: Molecular pharming is to use plant cells as bioreactors to produce various valuable proteins or peptides at large scales for pharmaceutical and nutritional uses.Since the last two decades,the molecular pharming industry is expanding at an accelerating pace in the developed countries due to the advantages of low cost,easily scale up and pathogen-free over other exogenous protein expression systems.In this review,we describe the progress of molecular pharming on expression systems,recombinant protein processing,and marketing.Also,the advantages and disadvantages of each system are discussed.In addition,we provide valuable information about the plant-made pharmaceuticals(PMP) products having reached or close to the market.It would be helpful for scientists who are working on this field.