Research progress on miR396-GRF module regulating plant stress response

The miR396-GRF module is a novel and efficient plant growth and development regulatory module. In this module, miR396 negatively regulates growth-regulating factor (GRF), affects the signal transduction pathway in the process of plant growth and development, and participates in the response of plants to abiotic stress (e.g., drought, salt damage, temperature, and UV-B radiation) and biological stress (e.g., cyst nematodes and pathogens). In this review, we discuss the regulatory network of the miR396-GRF module and the response mechanism involved in plant stress resistance, and further discuss related research trends and existing problems to provide a theoretical reference for future research on GRF.