Research progress on establishment and application of genetic transformation system of Salvia miltiorrhiza Bunge

Salvia miltiorrhiza Bunge is a traditional Chinese medicine widely used in the treatment of cardiovascular and cerebrovascular diseases due to its active components tanshinone and salvianolic acid. The establishment of an efficient and stable genetic transformation system and directional improvement of S. miltiorrhiza provide the possibility for industrial production of tanshinone and salvianolic acid and improvement in S. miltiorrhiza yield and quality. This paper studied both at home and abroad, and has carried on the system summary of S. miltiorrhiza genetic transformation method, from the explants, culture medium and the concentration of microbial factors affecting S. miltiorrhiza genetic transformation were summarized, for nearly five years of S.miltiorrhiza genetic transformation research, summarized the key enzyme genes and transcription factors. The future research focus was prospected to provide reference for improving the efficiency of genetic transformation and promoting the development of S. miltiorrhiza industry.